2018-06-28 10:32:172025-05-15 05:03:14
title
yrvN
rarA
description
similar to the E. coli recombination factor RarA, that is involved in processing recombination intermediates at replication forks
DNA-dependent ATPase, recombination factor, involved in processing recombination intermediates at replication forks
locus
BSU27530
BSU_27530
geneLength
1263
1266
function
DNA recombination
control of the access of the replication machinery to a collapsed replication fork
product
unknown
[[protein|RecA]] accessory protein, DNA-dependent ATPase
names
yrvN
rarA
rarA
yrvN
outlinks
bsu
BSU27530
BSU_27530
Gene
Coordinates
2,812,336 → 2,813,601
2,812,336 2,813,601
Biological materials
Mutant
MGNA-A827 (yrvN::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/827 NBRP B. subtilis, Japan]
BKE27530 (Δ[[gene|rarA]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE27530 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTATCATCTCTCCTTAC, downstream forward: _UP4_TAAAACAAAAAAACAGCCTT
BKK27530 (Δ[[gene|rarA]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK27530 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTATCATCTCTCCTTAC, downstream forward: _UP4_TAAAACAAAAAAACAGCCTT
MGNA-A827 (yrvN::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/827 NBRP B. subtilis, Japan]
BKE27530 ([[gene|rarA]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE27530 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTATCATCTCTCCTTAC, downstream forward: _UP4_TAAAACAAAAAAACAGCCTT
BKK27530 ([[gene|rarA]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK27530 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTATCATCTCTCCTTAC, downstream forward: _UP4_TAAAACAAAAAAACAGCCTT
References
Gene
Phenotypes of a mutant
sensitive to H2O2 [pubmed|30954900]
reduced viability of [[gene|rarA]] [[gene|recA]] or [[gene|rarA]] [[gene|recO]] double mutants [pubmed|32117122]
The protein
Catalyzed reaction/ biological activity
inhibits [[protein|PriA]]-dependent initiation of [[category|DNA replication]] [pubmed|29947798]
contributes to error-prone DNA repair, links re-initiation of DNA replication with repair-by-recombination by controlling the access of the replication machinery to a collapsed replication fork [pubmed|30954900]
contributes to the assembly of RecA nucleoprotein filaments onto single-stranded DNA [pubmed|32117122]
The protein
Protein family
[SW|AAA ATPase family] (according to UniProt)
The protein
Paralogous protein(s)
[[this]]
The protein
Effectors of protein activity
ATPase is stimulated by ssDNAdsDNA junctions or dsDNA ends [pubmed|29947798]
ssDNA-dependent ATPase is stimulated by [[protein|SsbA]] bound to ssDNA [pubmed|29947798]